| Monday 12th of June |
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| 13.00-18.00 |
Registration |
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| 13.00-14.00 |
Lunch (available upon request) |
| 14.00-16.00 |
Management Committee and Core Group Meeting (MC- and CG-members only) |
| 16.00-16.30 |
Coffee Break |
| 16:30-16:45 |
Welcome and Opening remarks |
| 16.45-17.45 |
Working groups sessions for each Work Package (open to all participants) |
| 17.45-18.00 |
Short break |
| 18.00-19.00 |
The EMBO Keynote Lecture: Ivan Dikic (Institute of Biochemistry II Goethe University Medical Faculty, DE), PROXIDRUGS in infectious diseases |
| 19.00-19.30 |
Tribute to Alfred L. Goldberg - by Olivier Coux and Michael Glickman |
| 19.30-21.00 |
Reception |
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| Tuesday 13th of June |
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Session I: Proteasome-dependent proteolysis |
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Chairs: Silke Meiners (Research Center Borstel, DE) and Niki Chondrogianni (National Hellenic Research Foundation, GR) |
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| 8.30-9.00 |
Keynote speaker: Michael Glickman (Technion Israel Institute of Technology, IL), Proteasome, would you like ubiquitin with your substrate? |
| 9.00-9.10 |
Matthias Stein (Max Planck Institute for Dynamics of Complex Technical Systems, DE), Control and regulation of NF-κB signaling by deubiquitinylases |
| 9.10-9.20 |
Gunnar Dittmar (Luxembourg Institute of Health, LU), Peptide-based interactomics of the claudin family identifies a linear motif that recruits the proteasome to the Tight-junctions |
| 9.20-9.35 |
Flash talks I |
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Dina Franić (School of Medicine Zagreb, HR), Quality control of misfolded proteins in quiescent yeast Saccharomyces cerevisiae relies on selective protein degradation |
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Junyi He (Technion, IL), Identification and characterization of novel quality control factors acting in a co-translational manner |
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Wendy Xolalpa-Villanueva (National Autonomous University of Mexico, MX), Designing chimeric deubiquitinating enzymes with preference for homotypic K63 ubiquitin chains |
| 9.35-10.00 |
Coffee break |
| 10.00-10.30 |
Keynote speaker: Michal Sharon (Weizmann Institute of Science, IL), Systematic Identification of 20S Proteasome Substrates |
| 10.30-10.40 |
Christine Blattner (Karlsruhe Institute of Technology, DE), Regulation of p300 by TRIM25 |
| 10.40-11.00 |
Flash talks II |
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Hila Ben-arie Zilberman (Technion, IL), Unraveling the Influence of ISG15 and ISGylation on translation |
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Laura Costa-Sastre (Universitat de Barcelona, ES), Regulation of adipose tissue homeostasis and energy balance by the ubiquitin ligase HERC1 |
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Martin Horn (Czech Academy of Sciences, CZ), Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes |
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Gema Gorjón-de-Pablo (Josep Carreras Leukaemia Research Institute, ES), Design and functional characterization of a first-in-class irreversible inhibitor of HOIL-1-interacting protein (HOIP) with selective antitumor activity against B-cell non-Hodgkin lymphoma |
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Veronica Muratore (CIC bioGUNE, ES), MIB1 and USP21 regulate the stability of the centrosomal protein LUZP1, a mediator of Townes-Brocks Syndrome |
| 11.00-12.30 |
Lunch break |
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| 12.30-17.30 |
Excursion to Neanderthal Museum in Krapina |
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| 17.30-19.00 |
Dinner break |
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Session II: Lysosome-dependent proteolysis and Autophagy |
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Chairs: Germana Meroni (University of Trieste, IT) and Devrim Gözüaçik (Koç University, TR) |
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| 19.00-19.30 |
Keynote speaker: Jörn Dengjel (University of Fribourg, CH), New insights into phosphorylation-based regulation of autophagy |
| 19.30-19.40 |
Ivana Novak Nakir (University of Split, School of Medicine, HR), Regulation of BNIP3L/NIX receptor dimerization in development-induced mitophagy |
| 19.40-19.50 |
Joan Sala-Gaston (Universitat de Barcelona, ES), Regulation of autophagy by the ubiquitin ligase HERC2 through the USP20/ULK1 axis |
| 19.50-20.00 |
Corentin Bouvier (CNRS Toulouse, FR), The ubiquitin ligase TRIM24 regulates apoptosis in bortezomib-resistant mantle cell lymphoma cells |
| 20.00-21.30 |
Poster Session with drinks |
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| Wednesday 14th of June |
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Session III: Protein quality control |
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Chairs: Rosa Barrio (CIC bioGUNE, ES) and Marija Vidović (University of Belgrade, RS) |
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| 9.00-9.30 |
Keynote speaker: Tommer Ravid (The Hebrew University of Jerusalem, IL), How can we employ the ubiquitin system for improving proteostasis? |
| 9.30-9.40 |
Ayala Shiber (Technion, IL), Identification and characterization of novel quality control factors acting on the ribosome |
| 9.40-9.50 |
Inês Lages (University of Trieste, IT), Identification of Deubiquitinases (DUBs) associated with TRIM18/MID1 |
| 9.50-10.00 |
Vasileios Voutsinos (University of Copenhagen, DK), A mutational atlas for Parkin proteostasis |
| 10.00-10.20 |
Flash talks III |
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Lu Xiong (University of Trieste, IT), Role of TRIM32, the ubiquitin ligase mutated in Limb Girdle Muscular Dystrophy R8 |
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Reet Kurg (University of Tartu, EE), The intrinsically disordered N-terminus of cancer-testis antigen MAGEA10 is responsible for its expression, nuclear localization and aberrant migration |
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Anna Aalto (Åbo Akademi, FI), Met1-linked ubiquitination during pathogenic and sterile inflammation |
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Clément Daviaud (CNRS - UMR7266, FR), An original oligosaccharide with anti-inflammatory activities |
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Jose Luis Castaño, (Instituto de Investigación Marqués de Valdecilla (IDIVAL), ES), LYN kinase show an elevated level of NEDDylation in chronic lymphocytic leukemia conditioning its stability and functionality |
| 10.20-11.00 |
Coffee break |
| 11.00-11.30 |
Keynote speaker: Ulrike Topf (Polish Academy of Sciences, PL), Non-canonical functions of the co-chaperone prefoldin in mitochondrial and cytosolic protein homeostasis |
| 11.30-11.40 |
Pedro Domingos (Universidade Nova de Lisboa, PT), Xport-A functions as a chaperone by stabilizing the first five transmembrane domains of Rhodopsin-1 |
| 11.40-12.10 |
STSM experience talks (5 talks of 3-5 min) |
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Katarina Petra Van Midden (University of Ljubljana, SI), CEP1, a papain-like cysteine protease from Chlamydomonas reinhardtii with transpeptidase activity |
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Roger Castaño-Muñiz (Universitat de Barcelona, ES), Drugging the FBXW7 E3 ligase with a fragment-based approach |
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María Blanquer (CIMUS, ES), Potential impact of SUMO on PrP-based neurodegenerative diseases |
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Marta Lavouras Mendes (Luxembourg Institute of Health, LU) |
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Corentin Bouvier (CNRS Toulouse, FR): Targeting the proteaphagy receptor p62 with structure-based drug discovery approaches |
| 12.10-14.00 |
Lunch break |
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| 14.00-15.30 |
Working groups sessions for each WP / Free time for a walk in the city |
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Session IV: Ubiquitin-like modifiers |
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Chairs: Elah Pick (University of Haifa, IL) and Alfred Vertegaal (Leiden University Medical Center, NL) |
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| 15.30-16.00 |
Keynote speaker: Ron Hay (University of Dundee, UK), Role of the p97 segregase in arsenic induced degradation of PML |
| 16.00-16.10 |
Orhi Barroso-Gomila (CIC bioGUNE, ES), BioE3 enables the identification of bona fide targets of E3 ligases |
| 16.10-16.20 |
Jose Luis Castaño(Instituto de Investigación Marqués de Valdecilla (IDIVAL), ES), LYN kinase show an elevated level of NEDDylation in chronic lymphocytic leukemia conditioning its stability and functionality |
| 16.20-16.30 |
Yanis Hichem Bouzaher (University of Santiago de Compostela),Modulation of the antiviral and anti-apoptotic activities of ISG15 by SUMO |
| 16.30-16.40 |
Georgia Chachami (University of Thessaly, GR), Deciphering the role of sumoylation in EXOSC10 function and its impact on cancer cells adaptation during hypoxia (STSM experience) |
| 16.45-16.55 |
Dimitris Xirodimas (CRBM-CNRS, FR), Presenting the ProteoCure NEDD8/Rub1 subgroup / NEDD8, Stress Granules and neurodegeneration. Targeting NEDP1 to ameliorate ALS phenotypes through stress granules disassembly |
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| 19.00-22.00 |
Conference Dinner |
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| Thursday 15th of June |
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Session V: Proteolytic processing and Protease Targets |
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Chairs: Klaudia Brix (Constructor University, DE) and Hans Brandstetter (Paris Lodron University Salzburg, AT) |
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| 8.30-9.00 |
Keynote speaker: Agnès Noël (University of Liège, BE), Multifaceted MT4-MMP in cancer progression |
| 9.00-9.10 |
Gilles Lalmanach (University of Tours, FR), Alteration of lung barrier integrity and epithelial permeability by cigarette smoke-elicited cysteine cathepsin S during COPD |
| 9.10-9.20 |
Kvido Strisovsky (IOCB Prague, CZ), Mechanism and inhibition of rhomboid intramembrane proteases |
| 9.20-9.50 |
Keynote speaker: Marina Klemenčić (University of Ljubljana, SI), Proteolysis and peptide ligation; deciphering the two enzymatic mechanisms using activity-based probes |
| 9.50-10.00 |
Emmanuelle Liaudet-Coopman (INSERM U1194, FR), Proteolysis of the matricellular SPARC protein by cathepsin D in the triple-negative breast cancer microenvironment |
| 10.00-10.10 |
Rigmor Solberg (University of Oslo, NO), Regulation and functions of the mammalian cysteine protease legumain in health and diseases |
| 10.10-10.30 |
Coffee break |
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Session VI: Proteolysis in Disease |
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Chairs: Heike Laman (University of Cambridge, GB) and Nico Dantuma (Karolinska Institute, SE) |
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| 10.30-11.00 |
Keynote speaker: Stefan Pöhlmann (Georg August University Göttinngen, DE), Proteolytic activation of SARS-CoV-2 and its inhibition |
| 11.00-11.10 |
Justyna McIntyre (Polish Academy of Sciences, PL), E3 ubiquitin ligase RNF2 regulates the cellular level of human most mutagenic DNA polymerase - polymerase iota |
| 11.10-11.20 |
Nuray Erin (Akdeniz University, TR), Immune regulatory roles of ADAM10 and Neprilysin in metastatic breast carcinoma |
| 11.20-11.40 |
Coffee break |
| 11.40-11.50 |
Daniel Taillandier (INRAE, FR), The MuRF1-E2 network: search for inhibitors impeding muscle atrophy |
| 11.50-12.00 |
Alfred Vertegaal (Leiden University Medical Center, NL), Ubiquitin E1 Inhibitor TAK-243 Activates the Immune System in a Preclinical Pancreatic Cancer Model |
| 12.00-12.10 |
Rosa Farràs (Centro de Investigación Príncipe Felipe, ES), Unveiling AP-1/JUNB's Role in Cell Cycle Control and Tumorigenic Invasion |
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| 12.10-12.30 |
Closing remarks |
| 12.30-13.30 |
Lunch or lunchbox - available upon request. |
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