Scientific Program

 

Monday 12th of June  
   
13.00-18.00 Registration 
   
13.00-14.00 Lunch (available upon request)
14.00-16.00 Management Committee and Core Group Meeting (MC- and CG-members only)
16.00-16.30 Coffee Break 
16:30-16:45 Welcome and Opening remarks 
16.45-17.45 Working groups sessions for each Work Package (open to all participants)
17.45-18.00 Short break
18.00-19.00 The EMBO Keynote Lecture: Ivan Dikic (Institute of Biochemistry II Goethe University Medical Faculty, DE), PROXIDRUGS in infectious diseases
19.00-19.30 Tribute to Alfred L. Goldberg - by Olivier Coux and Michael Glickman
19.30-21.00 Reception 
   
Tuesday 13th of June  
  Session I: Proteasome-dependent proteolysis 
  Chairs: Silke Meiners (Research Center Borstel, DE) and Niki Chondrogianni (National Hellenic Research Foundation, GR)
   
8.30-9.00 Keynote speaker: Michael Glickman (Technion Israel Institute of Technology, IL), Proteasome, would you like ubiquitin with your substrate?
9.00-9.10  Matthias Stein (Max Planck Institute for Dynamics of Complex Technical Systems, DE), Control and regulation of NF-κB signaling by deubiquitinylases
9.10-9.20 Gunnar Dittmar (Luxembourg Institute of Health, LU), Peptide-based interactomics of the claudin family identifies a linear motif that recruits the proteasome to the Tight-junctions
9.20-9.35 Flash talks I  
  Dina Franić (School of Medicine Zagreb, HR), Quality control of misfolded proteins in quiescent yeast Saccharomyces cerevisiae relies on selective protein degradation
  Junyi He (Technion, IL), Identification and characterization of novel quality control factors acting in a co-translational manner
  Wendy Xolalpa-Villanueva (National Autonomous University of Mexico, MX), Designing chimeric deubiquitinating enzymes with preference for homotypic K63 ubiquitin chains
9.35-10.00 Coffee break
10.00-10.30  Keynote speaker: Michal Sharon (Weizmann Institute of Science, IL), Systematic Identification of 20S Proteasome Substrates
10.30-10.40  Christine Blattner (Karlsruhe Institute of Technology, DE), Regulation of p300 by TRIM25
10.40-11.00 Flash talks II  
  Hila Ben-arie Zilberman (Technion, IL), Unraveling the Influence of ISG15 and ISGylation on translation
  Laura Costa-Sastre (Universitat de Barcelona, ES), Regulation of adipose tissue homeostasis and energy balance by the ubiquitin ligase HERC1
  Martin Horn (Czech Academy of Sciences, CZ), Highly potent inhibitors of cathepsin K with a differently positioned cyanohydrazide warhead: structural analysis of binding mode to mature and zymogen-like enzymes
  Gema Gorjón-de-Pablo (Josep Carreras Leukaemia Research Institute, ES), Design and functional characterization of a first-in-class irreversible inhibitor of HOIL-1-interacting protein (HOIP) with selective antitumor activity against B-cell non-Hodgkin lymphoma
  Veronica Muratore (CIC bioGUNE, ES), MIB1 and USP21 regulate the stability of the centrosomal protein LUZP1, a mediator of Townes-Brocks Syndrome
11.00-12.30 Lunch break 
   
12.30-17.30 Excursion to Neanderthal Museum in Krapina 
   
17.30-19.00 Dinner break
   
  Session II: Lysosome-dependent proteolysis and Autophagy
  Chairs: Germana Meroni (University of Trieste, IT) and Devrim Gözüaçik (Koç University, TR)
   
19.00-19.30 Keynote speaker: Jörn Dengjel (University of Fribourg, CH), New insights into phosphorylation-based regulation of autophagy
19.30-19.40 Ivana Novak Nakir (University of Split, School of Medicine, HR), Regulation of BNIP3L/NIX receptor dimerization in development-induced mitophagy
19.40-19.50 Joan Sala-Gaston (Universitat de Barcelona, ES), Regulation of autophagy by the ubiquitin ligase HERC2 through the USP20/ULK1 axis 
19.50-20.00 Corentin Bouvier (CNRS Toulouse, FR), The ubiquitin ligase TRIM24 regulates apoptosis in bortezomib-resistant mantle cell lymphoma cells
20.00-21.30 Poster Session with drinks 
   
Wednesday 14th of June  
  Session III: Protein quality control
  Chairs: Rosa Barrio (CIC bioGUNE, ES) and Marija Vidović (University of Belgrade, RS)
   
9.00-9.30 Keynote speaker: Tommer Ravid (The Hebrew University of Jerusalem, IL), How can we employ the ubiquitin system for improving proteostasis?
9.30-9.40  Ayala Shiber (Technion, IL), Identification and characterization of novel quality control factors acting on the ribosome
9.40-9.50 Inês Lages (University of Trieste, IT), Identification of Deubiquitinases (DUBs) associated with TRIM18/MID1
9.50-10.00 Vasileios Voutsinos (University of Copenhagen, DK), A mutational atlas for Parkin proteostasis
10.00-10.20 Flash talks III   
  Lu Xiong (University of Trieste, IT), Role of TRIM32, the ubiquitin ligase mutated in Limb Girdle Muscular Dystrophy R8
  Reet Kurg (University of Tartu, EE), The intrinsically disordered N-terminus of cancer-testis antigen MAGEA10 is responsible for its expression, nuclear localization and aberrant migration
  Anna Aalto (Åbo Akademi, FI), Met1-linked ubiquitination during pathogenic and sterile inflammation
  Clément Daviaud (CNRS - UMR7266, FR), An original oligosaccharide with anti-inflammatory activities
  Jose Luis Castaño, (Instituto de Investigación Marqués de Valdecilla (IDIVAL), ES), LYN kinase show an elevated level of NEDDylation in chronic lymphocytic leukemia conditioning its stability and functionality
10.20-11.00 Coffee break 
11.00-11.30 Keynote speaker: Ulrike Topf (Polish Academy of Sciences, PL), Non-canonical functions of the co-chaperone prefoldin in mitochondrial and cytosolic protein homeostasis
11.30-11.40 Pedro Domingos (Universidade Nova de Lisboa, PT),  Xport-A functions as a chaperone by stabilizing the first five transmembrane domains of Rhodopsin-1
11.40-12.10 STSM experience talks (5 talks of 3-5 min) 
  Katarina Petra Van Midden (University of Ljubljana, SI), CEP1, a papain-like cysteine protease from Chlamydomonas reinhardtii with transpeptidase activity
  Roger Castaño-Muñiz (Universitat de Barcelona, ES), Drugging the FBXW7 E3 ligase with a fragment-based approach
  María Blanquer (CIMUS, ES), Potential impact of SUMO on PrP-based neurodegenerative diseases
  Marta Lavouras Mendes (Luxembourg Institute of Health, LU)
  Corentin Bouvier (CNRS Toulouse, FR): Targeting the proteaphagy receptor p62 with structure-based drug discovery approaches
12.10-14.00 Lunch break
   
14.00-15.30 Working groups sessions for each WP / Free time for a walk in the city 
   
  Session IV: Ubiquitin-like modifiers
  Chairs: Elah Pick (University of Haifa, IL) and Alfred Vertegaal (Leiden University Medical Center, NL)
   
15.30-16.00 Keynote speaker: Ron Hay (University of Dundee, UK), Role of the p97 segregase in arsenic induced degradation of PML
16.00-16.10  Orhi Barroso-Gomila (CIC bioGUNE, ES), BioE3 enables the identification of bona fide targets of E3 ligases
16.10-16.20 Jose Luis Castaño(Instituto de Investigación Marqués de Valdecilla (IDIVAL), ES), LYN kinase show an elevated level of NEDDylation in chronic lymphocytic leukemia conditioning its stability and functionality
16.20-16.30 Yanis Hichem Bouzaher (University of Santiago de Compostela),Modulation of the antiviral and anti-apoptotic activities of ISG15 by SUMO
16.30-16.40 Georgia Chachami (University of Thessaly, GR), Deciphering the role of sumoylation in EXOSC10 function and its impact on cancer cells adaptation during hypoxia (STSM experience)
16.45-16.55  Dimitris Xirodimas (CRBM-CNRS, FR), Presenting the ProteoCure NEDD8/Rub1 subgroup / NEDD8, Stress Granules and neurodegeneration. Targeting NEDP1 to ameliorate ALS phenotypes through stress granules disassembly
   
19.00-22.00 Conference Dinner 
   
Thursday 15th of June  
  Session V: Proteolytic processing and Protease Targets  
  Chairs: Klaudia Brix (Constructor University, DE) and Hans Brandstetter (Paris Lodron University Salzburg, AT)
   
8.30-9.00 Keynote speaker: Agnès Noël (University of Liège, BE), Multifaceted MT4-MMP in cancer progression
9.00-9.10  Gilles Lalmanach (University of Tours, FR), Alteration of lung barrier integrity and epithelial permeability by cigarette smoke-elicited cysteine cathepsin S during COPD
9.10-9.20 Kvido Strisovsky (IOCB Prague, CZ), Mechanism and inhibition of rhomboid intramembrane proteases
9.20-9.50  Keynote speaker: Marina Klemenčić (University of Ljubljana, SI), Proteolysis and peptide ligation; deciphering the two enzymatic mechanisms using activity-based probes
9.50-10.00  Emmanuelle Liaudet-Coopman (INSERM U1194, FR), Proteolysis of the matricellular SPARC protein by cathepsin D in the triple-negative breast cancer microenvironment
10.00-10.10 Rigmor Solberg (University of Oslo, NO), Regulation and functions of the mammalian cysteine protease legumain in health and diseases
10.10-10.30 Coffee break
   
  Session VI: Proteolysis in Disease
  Chairs: Heike Laman (University of Cambridge, GB) and Nico Dantuma (Karolinska Institute, SE)
   
10.30-11.00 Keynote speaker: Stefan Pöhlmann (Georg August University Göttinngen, DE), Proteolytic activation of SARS-CoV-2 and its inhibition 
11.00-11.10  Justyna McIntyre (Polish Academy of Sciences, PL), E3 ubiquitin ligase RNF2 regulates the cellular level of human most mutagenic DNA polymerase - polymerase iota
11.10-11.20 Nuray Erin (Akdeniz University, TR), Immune regulatory roles of ADAM10 and Neprilysin in metastatic breast carcinoma
11.20-11.40 Coffee break
11.40-11.50 Daniel Taillandier (INRAE, FR), The MuRF1-E2 network: search for inhibitors impeding muscle atrophy
11.50-12.00 Alfred Vertegaal (Leiden University Medical Center, NL), Ubiquitin E1 Inhibitor TAK-243 Activates the Immune System in a Preclinical Pancreatic Cancer Model
12.00-12.10 Rosa Farràs (Centro de Investigación Príncipe Felipe, ES), Unveiling AP-1/JUNB's Role in Cell Cycle Control and Tumorigenic Invasion
   
12.10-12.30 Closing remarks 
12.30-13.30 Lunch or lunchbox - available upon request. 

 

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